The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 15, 2013
Filed:
Nov. 17, 2009
Ulrich Iserloh, Hoboken, NJ (US);
Zhaoning Zhu, Plainsboro, NJ (US);
Andrew Stamford, Chatham Township, NJ (US);
Johannes H. Voigt, Cranford, NJ (US);
Ulrich Iserloh, Hoboken, NJ (US);
Zhaoning Zhu, Plainsboro, NJ (US);
Andrew Stamford, Chatham Township, NJ (US);
Johannes H. Voigt, Cranford, NJ (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt, solvate or ester thereof, wherein U, W, X, L, Y, M, Z, c, d, e, f, g, h, s, t, R, R, R, R, R, R, R, R, R, R, R, R, Rand Rare as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic magonist or mantagonist.