Triazolopyridine derivatives and their therapeutic use

Abstract

Compounds of formula (I) are inhibitors of p38 MAP kinase, useful as anti-inflammatory agents in the treatment of inter alia, diseases of the respiratory tract wherein; Ris C-Calkyl, C-Ccycloalkyl, phenyl which is optionally substituted, 5- or 6 membered monocyclic heteroaryl which is optionally substituted, or a radical of formula (II) wherein n is 1 or 2, and Rand Rare independently H or C-Calkyl, or Rand Rtaken together with the nitrogen to which they are attached form a 6-membered heterocyclic ring optionally containing a further heteroatom selected from N and O; Y is —O— or —S(O)— wherein p is 0, 1 or 2; A is an optionally substituted divalent arylene radical, or a mono- or bicyclic heteroarylene radical, or a C-Cdivalent cycloalkylene radical having 5 or 6 ring atoms, or a piperidinylene radical wherein the ring nitrogen is linked to RNHC(═O)W—; W is a bond, —NH— or —C(R)(R), wherein Rand Rare independently H, methyl, ethyl, amino, hydroxyl or halo; and Ris a radical as defined in the claims.