The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 15, 2013
Filed:
Aug. 27, 2008
Gattadahalli M. Anantharamaiah, Birmingham, AL (US);
David W. Garber, Birmingham, AL (US);
Geeta Datta, Pelham, AL (US);
Sheila P. Handattu, Vestavia Hills, AL (US);
Vinod K. Mishra, Homewood, AL (US);
Gattadahalli M. Anantharamaiah, Birmingham, AL (US);
David W. Garber, Birmingham, AL (US);
Geeta Datta, Pelham, AL (US);
Sheila P. Handattu, Vestavia Hills, AL (US);
Vinod K. Mishra, Homewood, AL (US);
UAB Research Foundation, Birmingham, AL (US);
Abstract
The present invention provides novel synthetic apolipoprotein E (ApoE)-mimicking peptides wherein the receptor binding domain of apolipoprotein E is covalently linked to 18A, the well characterized lipid-associating model class A amphipathic helical peptide, or a modified version thereof. Such peptides enhance low density lipoprotein (LDL) and very low density lipoprotein (VLDL) binding to and degradation by fibroblast or HepG2 cells. Also provided are possible applications of the synthetic peptides in lowering human plasma LDL/VLDL cholesterol levels, thus inhibiting atherosclerosis. The present invention also relates to synthetic peptides that can improve HDL function and/or exert anti-inflammatory properties.