The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 15, 2013
Filed:
May. 17, 2010
Mark S. F. Clarke, Houston, TX (US);
Alamelu Sundaresan, Sugarland, TX (US);
Neal R. Pellis, Pearland, TX (US);
Mark S. F. Clarke, Houston, TX (US);
Alamelu Sundaresan, Sugarland, TX (US);
Neal R. Pellis, Pearland, TX (US);
The United States of America as represented by the National Aeronautics and Space Administration, Washington, DC (US);
University of Houston, Houston, TX (US);
Universities Space Research Association, Columbia, MD (US);
Abstract
The present disclosure provides ex vivo-derived mineralized three-dimensional bone constructs. The bone constructs are obtained by culturing osteoblasts and osteoclast precursors under randomized gravity vector conditions. Preferably, the randomized gravity vector conditions are obtained using a low shear stress rotating bioreactor, such as a High Aspect Ratio Vessel (HARV) culture system. The bone constructs of the disclosure have utility in physiological studies of bone formation and bone function, in drug discovery, and in orthopedics.