The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 15, 2013
Filed:
Aug. 05, 2009
Andrew K. Ottens, Glen Allen, VA (US);
Firas H. Kobaissy, Gainesville, FL (US);
Ka-wang (Kevin) Wang, Gainesville, FL (US);
Ronald L. Hayes, Gainesville, FL (US);
Zhiqun Zhang, Gainesville, FL (US);
Ming Chen Liu, Gainesville, FL (US);
Monika Oli, Gainesville, FL (US);
Andrew K. Ottens, Glen Allen, VA (US);
Firas H. Kobaissy, Gainesville, FL (US);
Ka-Wang (Kevin) Wang, Gainesville, FL (US);
Ronald L. Hayes, Gainesville, FL (US);
Zhiqun Zhang, Gainesville, FL (US);
Ming Chen Liu, Gainesville, FL (US);
Monika Oli, Gainesville, FL (US);
University of Florida Research Foundation, Inc., Gainesville, FL (US);
Banyan Biomarkers, Inc., Alachua, FL (US);
Abstract
Collapsin response mediator proteins (CRMPs) decreased in tissue and increased in biological fluids after neural injury from traumatic brain injury (TBI). Significant decreases of CRMP1, CRMP2, CRMP4 and CRMP5 were accompanied by the appearance of distinct 58 kDa (CRMP-2) or 55 kDa (CRMP-4) breakdown products from proteolytic cleavage by calpain. Synaptotagmin breakdown products were also associated with TBI and could be detected along with intact protein in human cerebral spinal fluid (CSF). Both biomarkers were detected in human biofluid and related to recovery from traumatic brain injury.