The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 08, 2013
Filed:
Jul. 18, 2008
Dharmesh R. Tailor, Voorhees, NJ (US);
James E. Baumgardner, Folsom, PA (US);
Ravinder Reddy, Gladwyne, PA (US);
Dharmesh R. Tailor, Voorhees, NJ (US);
James E. Baumgardner, Folsom, PA (US);
Ravinder Reddy, Gladwyne, PA (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Abstract
Prior approaches have deliveredOto a subject by inhalation, but the relationship between local signal changes and metabolism has been complicated by HO created in non-cerebral tissues. During a brief pulse ofOinhalation, this arterial input function for HO is negligible due to convective transport delays. Additional delays in the arterial input function due to restricted diffusion of water makes pulsed inhalation ofOeven more effective. Accordingly, ventilator system are provided to deliverOas a brief pulse to a subject. Subsequent MR imaging demonstrates delayed appearance of HO in the cerebral ventricles, suggesting that the arterial input function of HO is delayed by restricted water diffusion in addition to convective transit delays. Delivery as a brief pulse therefore offers significant advantages in relating MR signal changes directly to metabolism.