The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 08, 2013
Filed:
Mar. 01, 2012
Wenge Zhong, Thousand Oaks, CA (US);
Stephen Hitchcock, Jupiter, FL (US);
Vinod F. Patel, Acton, MA (US);
Michael Croghan, Thousand Oaks, CA (US);
Thomas Dineen, Somerville, MA (US);
Scott Harried, Woodland Hills, CA (US);
Daniel Horne, Simi Valley, CA (US);
Ted Judd, Simi Valley, CA (US);
Matthew Walker, Ventura, CA (US);
Charles Kreiman, Watertown, MA (US);
Patricia Lopez, West Hills, CA (US);
Holger Monenschein, Jupiter, FL (US);
Thomas Nguyen, Thousand Oaks, CA (US);
Matthew Weiss, Boston, MA (US);
Qiufen Xue, Newbury Park, CA (US);
Bryant Yang, Simi Valley, CA (US);
Russell Graceffa, Hampton, NH (US);
Wenge Zhong, Thousand Oaks, CA (US);
Stephen Hitchcock, Jupiter, FL (US);
Vinod F. Patel, Acton, MA (US);
Michael Croghan, Thousand Oaks, CA (US);
Thomas Dineen, Somerville, MA (US);
Scott Harried, Woodland Hills, CA (US);
Daniel Horne, Simi Valley, CA (US);
Ted Judd, Simi Valley, CA (US);
Matthew Walker, Ventura, CA (US);
Charles Kreiman, Watertown, MA (US);
Patricia Lopez, West Hills, CA (US);
Holger Monenschein, Jupiter, FL (US);
Thomas Nguyen, Thousand Oaks, CA (US);
Matthew Weiss, Boston, MA (US);
Qiufen Xue, Newbury Park, CA (US);
Bryant Yang, Simi Valley, CA (US);
Russell Graceffa, Hampton, NH (US);
Amgen Inc., Thousand Oaks, CA (US);
Abstract
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase activity and for the treatment of diseases, including Alzheimer's disease (AD) and related CNS conditions, mediated thereby. In one embodiment, the compounds have a general Formula I or Formula II wherein R, B, Rand W of Formula I, and R, R, A, W, X, Z, m and n of Formula II are defined herein. The invention further provides compounds of Formula III and IV and sub-Formulas II-A-II-D and III-A-III-D. The compounds may be used in pharmaceutical compositions for treating, prophylactically or therapeutically, disorders related to the activity of beta-secretase protein, including without limitation, AD, cognitive deficits and impairment, schizophrenia and other similar central nervous system conditions.