The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 08, 2013
Filed:
Aug. 29, 2007
Stephan Fischer, Polling, DE;
Friederike Hesse, Munich, DE;
Hendrik Knoetgen, Penzberg, DE;
Kurt Lang, Penzberg, DE;
Joerg Thomas Regula, Munich, DE;
Christian Schantz, Munich, DE;
Andreas Schaubmar, Penzberg, DE;
Stephan Fischer, Polling, DE;
Friederike Hesse, Munich, DE;
Hendrik Knoetgen, Penzberg, DE;
Kurt Lang, Penzberg, DE;
Joerg Thomas Regula, Munich, DE;
Christian Schantz, Munich, DE;
Andreas Schaubmar, Penzberg, DE;
Hoffmann-La Roche Inc., Nutley, NJ (US);
Abstract
Method for the production of IGF-I, characterized by cultivating a prokaryotic host cell comprising an expression vector containing a nucleic acid encoding a fusion protein comprising said IGF-I N-terminally linked to the C-terminus of a propeptide, whereby said propeptide ends C-terminally with amino acids -Y-Pro, wherein Y is selected from the group consisting of Pro, Pro-Ala, Pro-Gly, Pro-Thr, Ala-Pro, Gly-Pro, Thr-Pro, Arg-Pro, or Pro-Arg-Pro, recovering and cleaving said fusion protein with IgA protease, and recovering said IGF-I. IGF-I is useful for the treatment of neurodegenerative disorders like Alzheimer's Disease.