The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 08, 2013

Filed:

Mar. 13, 2012
Applicants:

Asitha Abeywardane, Danbury, CT (US);

Michael J. Burke, Newtown, CT (US);

Thomas Martin Kirrane, Middlebury, CT (US);

Matthew Russell Netherton, Danbury, CT (US);

Anil Kumar Padyana, Oxford, CT (US);

Lana Louise Smith Keenan, Poughquag, NY (US);

Hidenori Takahashi, LaGrangeville, NY (US);

Michael Robert Turner, Danbury, CT (US);

Qiang Zhang, Woodbury, CT (US);

Qing Zhang, Tianjin, CN;

Inventors:

Asitha Abeywardane, Danbury, CT (US);

Michael J. Burke, Newtown, CT (US);

Thomas Martin Kirrane, Middlebury, CT (US);

Matthew Russell Netherton, Danbury, CT (US);

Anil Kumar Padyana, Oxford, CT (US);

Lana Louise Smith Keenan, Poughquag, NY (US);

Hidenori Takahashi, LaGrangeville, NY (US);

Michael Robert Turner, Danbury, CT (US);

Qiang Zhang, Woodbury, CT (US);

Qing Zhang, Tianjin, CN;

Assignee:

Boehringer Ingelheim International GmbH, Ingelheim am Rhein, DE;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/553 (2006.01); A61K 31/55 (2006.01); A61K 31/551 (2006.01); A61K 31/438 (2006.01); A61K 31/436 (2006.01); A61K 31/453 (2006.01); A61K 31/5377 (2006.01); A61K 31/40 (2006.01); A61K 31/4025 (2006.01); A61K 31/357 (2006.01); C07D 267/08 (2006.01); C07D 225/02 (2006.01); C07D 243/08 (2006.01); C07D 245/02 (2006.01); C07D 221/20 (2006.01); C07D 491/04 (2006.01); C07D 401/02 (2006.01); C07D 413/14 (2006.01); C07D 405/14 (2006.01); C07D 405/02 (2006.01); C07D 319/16 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates to compounds of formula (I): wherein Rto R, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene Ahydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.


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