The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 01, 2013
Filed:
Feb. 14, 2012
William Ortyn, Bainbridge, WA (US);
David Basiji, Seattle, WA (US);
Luchuan Liang, Woodinville, WA (US);
Vidya Venkatachalam, Bellevue, WA (US);
Philip Morrissey, Bellevue, WA (US);
William Ortyn, Bainbridge, WA (US);
David Basiji, Seattle, WA (US);
Luchuan Liang, Woodinville, WA (US);
Vidya Venkatachalam, Bellevue, WA (US);
Philip Morrissey, Bellevue, WA (US);
Amnis Corporation, Seattle, WA (US);
Abstract
Photometric and morphometric features derived from multi-mode imagery of cells in flow are used as a cell analyzer to determine if a marker corresponding to a cancer cell or precancerous cell is present in the population of cells imaged. An imaging system simultaneously acquires a plurality of images for each cell passing through the field of view of the imaging system. Acquiring a plurality of different images (i.e., bright field, dark field, and fluorescent images) facilitates the determination of different morphological and morphometric parameters. Simultaneously acquiring the plurality of images enables relatively large populations of cells to be rapidly imaged, so that relatively small numbers of cancer cells in a large population of cells can be detected. Initially, known cancer cells are imaged to enable a marker to be identified. Then, a sample that may include cancer cells is imaged to determine if the marker is present.