The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 01, 2013
Filed:
Feb. 19, 2010
Tatsuhiko Kodama, Tokyo, JP;
Takao Hamakubo, Tokyo, JP;
Hirofumi Doi, Tokyo, JP;
Akira Sugiyama, Tokyo, JP;
Kouhei Tsumoto, Tokyo, JP;
Tatsuhiko Kodama, Tokyo, JP;
Takao Hamakubo, Tokyo, JP;
Hirofumi Doi, Tokyo, JP;
Akira Sugiyama, Tokyo, JP;
Kouhei Tsumoto, Tokyo, JP;
The University of Tokyo, Tokyo, JP;
Perseus Proteomics Inc., Tokyo, JP;
Abstract
It is an object of the present invention to provide a mutant streptavidin wherein the immunogenicity (antigenicity) in mammals of a streptavidin is reduced. The present invention provides a mutant streptavidin, which comprises an amino acid sequence in which (a) the arginine residue at position 72 is substituted with another amino acid residue, and (b) any one or more of the tyrosine residue at position 10, the tyrosine residue at position 71, the glutamic acid residue at position 89, the arginine residue at position 91, and the glutamic acid residue at position 104 are substituted with other amino acid residues, with respect to the amino acid sequence of a core streptavidin as shown in SEQ ID NO: 2, and which has decreased immunogenicity as compared with that of a wild-type streptavidin.