logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8546526 B1

PDFFull Text
Date of Patent:
Oct. 01, 2013

Filed:

Oct. 09, 2006

Selective αvβ3 receptor peptide antagonist for therapeutic and diagnostic applications

Applicants:

Annarita Del Gatto, Torre del Grecco, IT;

Laura Zaccaro, Naples, IT;

Carlo Pedone, Naples, IT;

Michele Saviano, Milan, IT;

Inventors:

Annarita del Gatto, Torre del Grecco, IT;

Laura Zaccaro, Naples, IT;

Carlo Pedone, Naples, IT;

Michele Saviano, Milan, IT;

Assignee:

Advanced Accelerator Applications, Saint Genis Pouilly, FR;

Attorney:

Steinfl & Bruno LLP

Primary Examiner:

Maury Audet

Int. Cl.
CPC ...
A61K 38/12 (2006.01); A61K 38/00 (2006.01); A61K 38/04 (2006.01); C07K 5/00 (2006.01); C07K 7/00 (2006.01); C07K 16/00 (2006.01); C07K 17/00 (2006.01); C07K 1/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention is related to new peptide antagonists of αβreceptor, designed on the basis of the crystal structure of integrin αβin complex with c(RGDf[NMe]V) and the NMR structure of echistatin. These peptides are potent and selective antagonists of the αβreceptor and can be used as novel anticancer drugs and/or new class of diagnostic non-invasive tracers as suitable tools for αβ-targeted therapy and imaging.

Find Patent Forward Citations

Loading…