The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 01, 2013
Filed:
Feb. 26, 2010
Peter A. Crooks, Nicholasville, KY (US);
Linda P. Dwoskin, Lexington, KY (US);
Joshua Ayers, Wilmington, DE (US);
Vladimir Grinevich, Kernersville, NC (US);
Sangeetha Sumithran, Richmond, KY (US);
Peter A. Crooks, Nicholasville, KY (US);
Linda P. Dwoskin, Lexington, KY (US);
Joshua Ayers, Wilmington, DE (US);
Vladimir Grinevich, Kernersville, NC (US);
Sangeetha Sumithran, Richmond, KY (US);
University of Kentucky Research Foundation, Lexington, KY (US);
Abstract
N-n-Alkylation of nicotine converts nicotine from an agonist into an antagonist specifically for neuronal nicotinic acetylcholine receptor subtypes mediating nicotine-evoked dopamine release. Conformationally restricted analogs exhibit both high affinity and selectivity at this site, and are able to access the brain due to their ability to act as substrates for the blood-brain barrier choline transporter.