The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 01, 2013
Filed:
Jun. 05, 2007
Alan B. Cooper, West Caldwell, NJ (US);
Yongqi Deng, Newton, MA (US);
Gerald W. Shipps, Jr., Stoneham, MA (US);
Neng-yang Shih, Lexington, MA (US);
Hugh Y. Zhu, Scotch Plains, NJ (US);
Robert Sun, Natick, MA (US);
Joseph M. Kelly, Parlin, NJ (US);
Ronald J. Doll, Convent Station, NJ (US);
Yang Nan, Malden, MA (US);
Tong Wang, Cambridge, MA (US);
Jagdish A. Desai, Monroe Township, NJ (US);
James J-s Wang, Westfield, NJ (US);
Youhao Dong, Cambridge, MA (US);
Vincent S. Madison, Mountain Lakes, NJ (US);
LI Xiao, Cranbury, NJ (US);
Alan W. Hruza, Hackettstown, NJ (US);
M. Arshad Siddiqui, Newton, MA (US);
Ahmed A. Samatar, West Windsor, NJ (US);
Sunil Paliwal, Monroe Township, NJ (US);
Hon-chung Tsui, East Brunswick, NJ (US);
Azim Alan Celebi, Clark, NJ (US);
Yiji Wu, Scotch Plains, NJ (US);
Sobhana Babu Boga, Scotch Plains, NJ (US);
Abdul-basit Alhassan, Scotch Plains, NJ (US);
Xiaolei Gao, Scotch Plains, NJ (US);
Liang Zhu, Somerville, MA (US);
Mehul Patel, Waltham, MA (US);
Alan B. Cooper, West Caldwell, NJ (US);
Yongqi Deng, Newton, MA (US);
Gerald W. Shipps, Jr., Stoneham, MA (US);
Neng-Yang Shih, Lexington, MA (US);
Hugh Y. Zhu, Scotch Plains, NJ (US);
Robert Sun, Natick, MA (US);
Joseph M. Kelly, Parlin, NJ (US);
Ronald J. Doll, Convent Station, NJ (US);
Yang Nan, Malden, MA (US);
Tong Wang, Cambridge, MA (US);
Jagdish A. Desai, Monroe Township, NJ (US);
James J-S Wang, Westfield, NJ (US);
Youhao Dong, Cambridge, MA (US);
Vincent S. Madison, Mountain Lakes, NJ (US);
Li Xiao, Cranbury, NJ (US);
Alan W. Hruza, Hackettstown, NJ (US);
M. Arshad Siddiqui, Newton, MA (US);
Ahmed A. Samatar, West Windsor, NJ (US);
Sunil Paliwal, Monroe Township, NJ (US);
Hon-Chung Tsui, East Brunswick, NJ (US);
Azim Alan Celebi, Clark, NJ (US);
Yiji Wu, Scotch Plains, NJ (US);
Sobhana Babu Boga, Scotch Plains, NJ (US);
Abdul-Basit Alhassan, Scotch Plains, NJ (US);
Xiaolei Gao, Scotch Plains, NJ (US);
Liang Zhu, Somerville, MA (US);
Mehul Patel, Waltham, MA (US);
Merck Sharp & Dohme, Rahway, NJ (US);
Abstract
Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts, esters and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.