The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 01, 2013

Filed:

Sep. 23, 2011
Applicants:

Naotake Kobayashi, Osaka, JP;

Kazuo Ueda, Osaka, JP;

Naohiro Itoh, Shiga, JP;

Shinji Suzuki, Osaka, JP;

Gaku Sakaguchi, Shiga, JP;

Akira Kato, Shiga, JP;

Akira Yukimasa, Osaka, JP;

Akihiro Hori, Osaka, JP;

Yuji Koriyama, Osaka, JP;

Hidekazu Haraguchi, Osaka, JP;

Ken Yasui, Osaka, JP;

Yasuhiko Kanda, Osaka, JP;

Inventors:

Naotake Kobayashi, Osaka, JP;

Kazuo Ueda, Osaka, JP;

Naohiro Itoh, Shiga, JP;

Shinji Suzuki, Osaka, JP;

Gaku Sakaguchi, Shiga, JP;

Akira Kato, Shiga, JP;

Akira Yukimasa, Osaka, JP;

Akihiro Hori, Osaka, JP;

Yuji Koriyama, Osaka, JP;

Hidekazu Haraguchi, Osaka, JP;

Ken Yasui, Osaka, JP;

Yasuhiko Kanda, Osaka, JP;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 279/00 (2006.01); C07D 265/00 (2006.01); A61K 31/535 (2006.01); A61K 31/541 (2006.01);
U.S. Cl.
CPC ...
Abstract

A composition having BACE 1 inhibitory activity containing a compound represented by the formula (I): wherein ring A is an optionally substituted heterocyclic group;E is lower alkylene;X is S;Ris a hydrogen atom or lower alkyl;R, R, R, R, Rand Ris each independently a hydrogen atom, halogen, or hydroxy etc.;n and m are each independently an integer of 0 to 3;n+m is an integer of 0 to 3;Ris a hydrogen atom or substituted lower alkyl;or its pharmaceutically acceptable salt thereof.


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