The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 01, 2013
Filed:
Feb. 21, 2011
Guo-qiang Chen, Beijing, CN;
Zheng-jun LI, Beijing, CN;
Zhen-yu Shi, Mordialloc, AU;
Ying-ying Guo, Beijing, CN;
Jia Jian, Beijing, CN;
Qiong Wu, Beijing, CN;
Guo-Qiang Chen, Beijing, CN;
Zheng-Jun Li, Beijing, CN;
Zhen-Yu Shi, Mordialloc, AU;
Ying-Ying Guo, Beijing, CN;
Jia Jian, Beijing, CN;
Qiong Wu, Beijing, CN;
Tianjin Greenbio Material Co., Ltd., Tianjin, CN;
Abstract
Known attempts using engineered bacteria to produce P(3HB-co-4HB) with carbon sources that are structurally unrelated to 4-hydroxybutyrate resulted in relatively low 4HB monomer content of 1.5 to 5 mol %. The current invention provides recombinant hosts for producing P(3HB-co-4HB) wherein the plasmid including succinate semialdehyde dehydrogenase gene (sucD gene) and 4-hydroxybutyrate dehydrogenase gene (4hbD gene) further includes pyruvate decarboxylase promoter (P). It was found that the 4HB monomer content in P(3HB-co-4HB) is significantly enhanced to be over 20 mol %, in the range of 8.8 to 23 mol %.