The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 01, 2013
Filed:
Jan. 24, 2011
Applicants:
Sanjiv Ghanshani, Irvine, CA (US);
Linh Q. Le, Tustin, CA (US);
Yi Liu, Irvine, CA (US);
Lance E. Steward, Irvine, CA (US);
Inventors:
Sanjiv Ghanshani, Irvine, CA (US);
Linh Q. Le, Tustin, CA (US);
Yi Liu, Irvine, CA (US);
Lance E. Steward, Irvine, CA (US);
Assignee:
Allergan, Inc., Irvine, CA (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 9/52 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present specification discloses expression constructs comprising single-chain proteins comprising a di-chain loop region comprising an exogenous protease cleavage site and a protease that can cleave the exogenous protease cleavage site located within the di-chain loop, cell compositions comprising such expression construct, and intracellular methods of converting the single-chain protein into its di-chain form.