The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 24, 2013
Filed:
Oct. 04, 2010
Sean Stevens, San Diego, CA (US);
Andrew J. Murphy, Croton-on-Hudson, NY (US);
Richard Flavell, Guilford, CT (US);
Elizabeth Eynon, New Haven, CT (US);
Jorge Galan, New Haven, CT (US);
Tim Willinger, New Haven, CT (US);
Markus Manz, Zurich, CH;
Anthony Rongvaux, New Haven, CT (US);
George D. Yancopoulos, Yorktown Heights, NY (US);
Sean Stevens, San Diego, CA (US);
Andrew J. Murphy, Croton-on-Hudson, NY (US);
Richard Flavell, Guilford, CT (US);
Elizabeth Eynon, New Haven, CT (US);
Jorge Galan, New Haven, CT (US);
Tim Willinger, New Haven, CT (US);
Markus Manz, Zurich, CH;
Anthony Rongvaux, New Haven, CT (US);
George D. Yancopoulos, Yorktown Heights, NY (US);
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Yale University, New Haven, CT (US);
Institute for Research in Biomedicine, Bellinzona, CH;
Abstract
A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mIl2rg subunit gene; and optionally a humanization of the TPO gene is described. A RAG/Il2rg KO/hTPO knock-in mouse is described. A mouse engrafted with human hematopoietic stem cells (HSCs) that maintains a human immune cell (HIC) population derived from the HSCs and that is infectable by a human pathogen, e.g.,oris described. A mouse that models a human pathogen infection that is poorly modeled in mice is described, e.g., a mouse that models a human mycobacterial infection, wherein the mouse develops one or more granulomas comprising human immune cells. A mouse that comprises a human hematopoietic malignancy that originates from an early human hematopoietic cells is described, e.g., a myeloid leukemia or a myeloproliferative neoplasia.