The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 24, 2013
Filed:
Jun. 20, 2008
George A. Moniz, Cambridge, MA (US);
Matthew J. Frizzle, Dundas, CA;
Charles Bernard, Moorpark, CA (US);
Michael Martinelli, San Diego, CA (US);
Margaret M. Faul, Newbury Park, CA (US);
Roger Nani, Bronx, NY (US);
Jay Larrow, Wakefield, MA (US);
George A. Moniz, Cambridge, MA (US);
Matthew J. Frizzle, Dundas, CA;
Charles Bernard, Moorpark, CA (US);
Michael Martinelli, San Diego, CA (US);
Margaret M. Faul, Newbury Park, CA (US);
Roger Nani, Bronx, NY (US);
Jay Larrow, Wakefield, MA (US);
Amgen Inc., Thousand Oaks, CA (US);
Abstract
The present invention relates to methods of making compounds that inhibit 11-hydroxysteroid dehydrogenase type 1 enzyme (11-HSD1). One method comprises (a) contacting a compound of formula (II) sequentially with a chiral base in the presence of an amine, and an alkylating agent R3-LG, (b) contacting the product of (a) with an acid to form a salt, and (c) reacting the salt with a base to form the compound of formula (I), wherein Z, R1, R2, and R3 are defined herein.