The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 24, 2013
Filed:
Mar. 11, 2011
Megumi Maruyama, Osaka, JP;
Naoya Kinomura, Suita, JP;
Satoshi Nojima, Osaka, JP;
Masahiro Takamura, Osaka, JP;
Keisuke Kakiguchi, Osaka, JP;
Hiroto Tatamidani, Suita, JP;
Megumi Maruyama, Osaka, JP;
Naoya Kinomura, Suita, JP;
Satoshi Nojima, Osaka, JP;
Masahiro Takamura, Osaka, JP;
Keisuke Kakiguchi, Osaka, JP;
Hiroto Tatamidani, Suita, JP;
Dainippon Sumitomo Pharma Co., Ltd., Osaka, JP;
Abstract
The present invention provides compounds which show high effectiveness against positive symptoms, negative symptoms and cognitive dysfunction in schizophrenia and reduce conventional side-effect risks as well as have remarkable effects for central neurological diseases associated with cognitive dysfunction other than schizophrenia. N-Acyl cyclic amine derivatives of formula (1): wherein Arand Arare aryl or heteroaryl; V is nitrogen, or CR; Wis a single bond, —C(O)—, etc.; Wis C-alkylene; Wis a single bond, methylene, —NH—, —CR═CR—, etc.; Ring Q is a group of formula (a) in which n is 0 or 1; m is 0 to 2; k is 1 to 3; Z is a single bond, methylene, oxygen, etc.; R, Rand Rare each, same or different, hydrogen, hydroxyl, halogen, cyano, Calkyl, etc.; or pharmaceutically acceptable salts thereof are provided.