The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 24, 2013
Filed:
Apr. 25, 2008
Lucia Policastro, Buenos Aires, AR;
Hebe Duran, Buenos Aires, AR;
Osvaldo Podhajcer, Buenos Aires, AR;
Lucia Policastro, Buenos Aires, AR;
Hebe Duran, Buenos Aires, AR;
Osvaldo Podhajcer, Buenos Aires, AR;
Inis Biotech LLC, Milford, DE (US);
Fundacion Instituto Leloir, Buenos Aires, AR;
Comision Nacional de Energia Atomica (CNEA), Buenos Aires, AR;
Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Buenos Aires, AR;
Abstract
The invention provides promoters inducible by reactive oxygen species (ROS), capable of driving the expression of a gene of interest, particularly in a tumor cell. More particularly, it refers to promoters inducible by reactive oxygen species, that may be used to drive the expression of a gene of interest, such as a therapeutic gene, or a reporter gene for use in image diagnosis. The promoters comprise at least a fragment of a promoter sequence responsive to said reactive oxygen species, and corresponding to a gene highly expressed in cancer cells, wherein the fragment of the promoter sequence responsive to reactive oxygen species (ROS) is selected from the group of: the VE element of the VEGF promoter, the E6 element of the promoter of the EGR-1 gene, the MMP-1 element and a chimeric promoter containing an E6 element and a VE element. It also provides vectors carrying a human therapeutic or non therapeutic gene of interest, operably linked to said promoter sequence and compositions comprising the same.