The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 24, 2013
Filed:
Sep. 15, 2008
Kfir Oved, Givataim, IL;
Eran Eden, Haifa, IL;
Martin Akerman, Haifa, IL;
Roy Noy, Savyon, IL;
Michal Besser, Tel-Aviv, IL;
Yoram Reiter, Haifa, IL;
Kfir Oved, Givataim, IL;
Eran Eden, Haifa, IL;
Martin Akerman, Haifa, IL;
Roy Noy, Savyon, IL;
Michal Besser, Tel-Aviv, IL;
Yoram Reiter, Haifa, IL;
Technion Research & Development Foundation Limited, Haifa, IL;
Tel HaShomer Medical Research Infrastructure and Services Ltd., Ramat-Gan, IL;
Abstract
A method of determining responsiveness to cancer treatment is disclosed. The method comprises analyzing a frequency of tumor infiltrating lymphocytes (TILs) having a CD8CD28CD152signature in a sample of the subject, wherein a frequency of TILs having the CD8CD28CD152signature above a predetermined level is indicative of a positive responsiveness to cancer treatment. Other signatures reflecting responsiveness to cancer treatment are also disclosed. In addition, methods of treating cancer based on these signatures are also disclosed.