The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 24, 2013
Filed:
Aug. 30, 2004
Irwin J. Griffith, North Reading, MA (US);
Joanne Pollock, Arlington, MA (US);
Julian F. Bond, Weymouth, MA (US);
Richard D. Garman, Arlington, MA (US);
Mei-chang Kuo, Winchester, MA (US);
Stephen P. Powers, Waltham, MA (US);
Mark A. Exley, Brookline, MA (US);
Xian Chen, North Chelmsford, MA (US);
Ze'ev Shaked, Berkeley, CA (US);
Irwin J. Griffith, North Reading, MA (US);
Joanne Pollock, Arlington, MA (US);
Julian F. Bond, Weymouth, MA (US);
Richard D. Garman, Arlington, MA (US);
Mei-Chang Kuo, Winchester, MA (US);
Stephen P. Powers, Waltham, MA (US);
Mark A. Exley, Brookline, MA (US);
Xian Chen, North Chelmsford, MA (US);
Ze'ev Shaked, Berkeley, CA (US);
Merck Patent GmbH, Darmstadt, DE;
Abstract
The present invention provides nucleic acid sequences coding for themajor pollen allergen Cry j I, Cry j II, Jun s I and Jun v I and fragments or peptides thereof. The present invention also provides purified Cry j I, Cry j II, Jun s I and Jun v I and at least one fragment thereof produced in a host cell transformed with a nucleic acid sequence coding for Cry j I, Cry j II, Jun s I and Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I prepared synthetically. Cry j I, Cry j II, Jun s I and Jun v I and fragments thereof are useful for diagnosing, treating, and preventing Japanese cedar pollinosis. The present invention also provides isolated peptides of Cry j I and Cry j II. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of Cry j I or Cry j II. The invention also pertains to modified peptides having similar or enhanced therapeutic properties as the corresponding naturally-occurring allergen or portion thereof but having reduced side effects. Methods of treatment or of diagnosis of sensitivity to Japanese cedar pollens in an individual and therapeutic compositions, and multipeptide formulations comprising one or more peptides of the invention are also provided.