The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 24, 2013
Filed:
Mar. 18, 2010
Zhirong Chen, Hangzhou, CN;
Jianfeng Chen, Beijing, CN;
Hong Yin, Hangzhou, CN;
Hong Zhao, Beijing, CN;
Dan Qiu, Hangzhou, CN;
Lifang Shi, Shaoxing, CN;
Jiandong LI, Shaoxing, CN;
Guangwen Chu, Beijing, CN;
Lei Shao, Beijing, CN;
Zhirong Chen, Hangzhou, CN;
Jianfeng Chen, Beijing, CN;
Hong Yin, Hangzhou, CN;
Hong Zhao, Beijing, CN;
Dan Qiu, Hangzhou, CN;
Lifang Shi, Shaoxing, CN;
Jiandong Li, Shaoxing, CN;
Guangwen Chu, Beijing, CN;
Lei Shao, Beijing, CN;
Zhejiang NHU Company Ltd., Shaoxing, Zhejiang Province, CN;
Zhejiang University, Hangzhou, Zhejiang Province, CN;
Beijing University of Chemical Technology, Beijing, CN;
Abstract
A method of preparing nano-dispersed high-all-trans-carotenoid microcapsules is provided, comprising: preparing 10-20% carotenoid suspension by milling the high-all trans-carotenoid crystals with dichloromethane until the particle size thereof is in the range of 2-5 μm, then supplying the suspension together with preheated dichloromethane of another pass into a dissolving tank to obtain a solution of 0.5-2%; delivering the solution together with ethanol or isopropanol into a crystallization device having high gravity rotating packed bed simultaneously and continuously, and then into a wiped-film evaporator for desolvation until the solid content is 10-20%, then a transparent alcohol dispersion of carotenoid is obtained; mashing the alcohol dispersion together with an aqueous solution containing an antioxidant and protective colloid and spray drying to obtain nano-dispersed high-all-trans-carotenoid microcapsules. As the crystals are nano-dispersed and the content of trans-isomer is more than 90%, the carotenoid microcapsules of present inventions exhibit high bioavailability.