The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 17, 2013
Filed:
Jun. 16, 2009
George A. Moniz, Cambridge, MA (US);
Matthew J. Frizzle, Burlington, CA;
Charles Bernard, Moorpark, CA (US);
Michael Martinelli, San Diego, CA (US);
Margaret Faul, Newbury Park, CA (US);
Jay Larrow, Wakefield, MA (US);
Karl B. Hansen, Cohasset, MA (US);
Liane Klingensmith, Stoughton, MA (US);
George A. Moniz, Cambridge, MA (US);
Matthew J. Frizzle, Burlington, CA;
Charles Bernard, Moorpark, CA (US);
Michael Martinelli, San Diego, CA (US);
Margaret Faul, Newbury Park, CA (US);
Jay Larrow, Wakefield, MA (US);
Karl B. Hansen, Cohasset, MA (US);
Liane Klingensmith, Stoughton, MA (US);
Amgen Inc., Thousand Oaks, CA (US);
Abstract
The present invention relates to methods of making compounds that inhibit 11-β-hydroxysteroid dehydrogenase type 1 enzyme (11-β HSD1). One method comprises (a) contacting a compound of formula (II) with a chiral base, deprotonating agent, and an alkylating agent R-LG, (b) contacting the product of (a) with an acid to form a salt, and (c) reacting the salt with a base to form the compound of formula (I); wherein Z, R, R, and Rare defined herein.