The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 17, 2013
Filed:
May. 28, 2009
Françoise Debart, Combaillaux, FR;
Jean-jacques Vasseur, Combaillaux, FR;
Thomas Lavergne, Saint Clement de Riviere, FR;
Françoise Debart, Combaillaux, FR;
Jean-Jacques Vasseur, Combaillaux, FR;
Thomas Lavergne, Saint Clement de Riviere, FR;
Centre National de la Recherche Scientifique, Paris, FR;
Universite Montpellier 2, Montpellier, FR;
Abstract
The invention relates to a method for the chemical synthesis of RNA, comprising the following steps: a) bonding to a solid support of a monomer having formula (II) in which—Xis a dimethoxytrityl group,—Xis H or an OAc group or OX, in which Xis a group having formula (A), in which X is O or S, R' is H or CHand R is selected from a linear or branched alkyl group at Cto Cand a R—O—Rgroup in which Ris an alkyl group at Cto Cand Ris a CHgroup or CHCH—O—CHor aryl; b) assembly with the monomer having formula (II) bound to the support thereof obtained in step (a) of at least one monomer having formula (III) in which X, Bp, Xare as defined for formula (II) and Xis a hydrogen phosphonate monoester or phosphoramidite group, preferably a 2-cyanoethyl-N,N-diisopropylphosphoramidite group, which is used to obtain a protected single-strand RNA bound to a support.