The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 17, 2013
Filed:
Sep. 27, 2007
Anup K Ray, Staten Island, NY (US);
Hiren V Patel, Fords, NJ (US);
Johannes Ludescher, Breitenbach, AT;
Mariappan Anbazhagan, Monmouth Junction, NJ (US);
Mahendra R Patel, Milltown, NJ (US);
Ingolf Macher, Woergl, AT;
Anup K Ray, Staten Island, NY (US);
Hiren V Patel, Fords, NJ (US);
Johannes Ludescher, Breitenbach, AT;
Mariappan Anbazhagan, Monmouth Junction, NJ (US);
Mahendra R Patel, Milltown, NJ (US);
Ingolf Macher, Woergl, AT;
Sandoz AG, Basel, CH;
Abstract
The present invention relates to an improved process for preparing a polypeptide or pharmaceutically acceptable salt thereof comprising L-tyrosine, L-alanine, L-glutamate, and L-lysine. The polypeptide or pharmaceutically acceptable salt thereof is preferably glatiramer acetate. The process comprises: (a) polymerizing a mixture of N-carboxyanhydride of L-tyrosine, N-carboxyanhydride of L-alanine, N-carboxyanhydride of a protected L-glutamate and N-carboxyanhydride of a protected L-lysine, in a polar aprotic solvent in the presence of an initiator, to form a protected polypeptide; (b) admixing an acid with the protected polypeptide formed in Step (a) and a solvent, to form a product; and (c) admixing a substance selected from the group consisting of an alkali or alkaline earth metal hydroxide, a carbonate, a hydrogencarbonate, and mixtures thereof, with the product formed in Step (b), and a solvent or a mixture of a solvent and water, to form a deprotected polypeptide or a pharmaceutically acceptable salt thereof.