The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 17, 2013
Filed:
May. 04, 2012
Martin Gleave, Vancouver, CA;
Paul S. Rennie, Richmond, CA;
Hideaki Miyake, Vancouver, CA;
Colleen Nelson, Surrey, CA;
Martin Gleave, Vancouver, CA;
Paul S. Rennie, Richmond, CA;
Hideaki Miyake, Vancouver, CA;
Colleen Nelson, Surrey, CA;
Teva Pharmaceutical Industries Ltd., Petach-Tikva, IL;
Abstract
It has now been determined that antisense therapy which reduces the expression of TRPM-provides therapeutic benefits in the treatment of cancer. Addition of antisense TRPM-ODN to prostatic tumor cells in vivo is effective for delaying the onset of androgen independence. Combined use of antisense TRPM-and taxanes synergistically enhances cytotoxic chemosensitivity of androgen-independent prostate cancer. In addition, it has also been found that antisense TRPM-has beneficial effect for other cancer types. Specifically, antisense TRPM-ODN enhances chemosensitivity in human Renal cell cancer, a normally chemoresistant disease with no active chemotherapeutic agent having an objective response rate higher than%. Radiation sensitivity is also enhanced when cells expressing TRPM-are treated with antisense TRPM-ODN. Thus, the antisense TRPM-ODNs can be used to enhance hormone sensitivity, chemosensitivity and radiation sensitivity of a variety of cancer types in which expression of TRPM-has been observed.