The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 10, 2013
Filed:
Sep. 17, 2010
Jamie Singer, Knoxville, TN (US);
Eric A. Wachter, Oak Ridge, TN (US);
Timothy Scott, Knoxville, TN (US);
Marlon Lutz, Chicago, IL (US);
Kevin Babiak, Evanston, IL (US);
Jamie Singer, Knoxville, TN (US);
Eric A. Wachter, Oak Ridge, TN (US);
Timothy Scott, Knoxville, TN (US);
Marlon Lutz, Chicago, IL (US);
Kevin Babiak, Evanston, IL (US);
Provectus Pharmaceuticals, Inc., Knoxville, TN (US);
Abstract
A new process for the manufacture of iodinated xanthenes in high purity includes a cyclization step followed by an iodination step. No extraction, chromatographic or solvent concentration steps are required, and the intermediate as well as final compounds are isolated via filtration or similar means. The process requires a single organic solvent, and the steps are completed at temperatures below 100° C. The exclusion of chloride ions, of chloride free-radicals, hypochlorite ions, or hypochlorous acid as reagents or from reagents that may generate these species in situ in the presence of oxidants, prevents undesirable impurity formation. Several new compounds have been conceived and isolated using these methods. These new compounds are also formed into new medicaments.