The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 10, 2013
Filed:
Jan. 06, 2011
Winfried S. Wels, Frankfurt am Main, DE;
Benjamin Daelken, Frankfurt am Main, DE;
Sylvia E. Schwarz, Frankfurt am Main, DE;
Winfried S. Wels, Frankfurt am Main, DE;
Benjamin Daelken, Frankfurt am Main, DE;
Sylvia E. Schwarz, Frankfurt am Main, DE;
Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus, Frankfurt am Main, DE;
Abstract
Object matter of the invention is an optimized DNA sequence encoding the scFv(FRP5) antibody fragment. This novel sequence prevents the generation of the undesired by-product in the context of an scFv(FRP5)-ETA fusion protein, and possibly also other bacterially expressed scFv(FRP5)-containing fusion proteins. The DNA sequence of the scFv(FRP5) domain of scFv(FRP5)-ETA was modified by exchanging a distinct codon, thereby preventing an otherwise possible internal start of protein translation.