The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 10, 2013
Filed:
Mar. 24, 2010
Samuel Helmer Gellman, Madison, WI (US);
Pil Seok Chae, Madison, WI (US);
Brian Kobilka, Palo Alto, CA (US);
Soren Rasmussen, Palo Alto, CA (US);
Samuel Helmer Gellman, Madison, WI (US);
Pil Seok Chae, Madison, WI (US);
Brian Kobilka, Palo Alto, CA (US);
Soren Rasmussen, Palo Alto, CA (US);
Wisconsin Alumni Research Foundation, Madison, WI (US);
The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);
Abstract
The invention provides amphiphilic compounds and methods for manipulating membrane proteins. Compounds of the invention, for example, the compounds of Formulas I-XIX, can be prepared from readily available starting materials. The amphiphilic compounds can manipulate membrane protein at relatively low concentrations compared to many known detergents. The compounds can be used to aid the isolation of membrane proteins, for example, to aid their solubilization and/or purification. The compounds can also be used to aid the functional and structural determination of membrane proteins, including their stabilization and crystallization.