The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 10, 2013
Filed:
Jun. 06, 2012
Onur Atasoylu, Izmir, TR;
Carlo Ballatore, Philadelphia, PA (US);
Kurt R. Brunden, Media, PA (US);
Longchuan Huang, Philadelphia, PA (US);
Donna M. Huryn, Allentown, NJ (US);
Michael James, Philadelphia, PA (US);
Virginia M. Y. Lee, Philadelphia, PA (US);
Francesco Piscitelli, Strongoli Marina, IT;
Amos B. Smith, Iii, Merion, PA (US);
James Soper, Cambridge, MA (US);
John Q. Trojanowski, Philadelphia, PA (US);
Onur Atasoylu, Izmir, TR;
Carlo Ballatore, Philadelphia, PA (US);
Kurt R. Brunden, Media, PA (US);
Longchuan Huang, Philadelphia, PA (US);
Donna M. Huryn, Allentown, NJ (US);
Michael James, Philadelphia, PA (US);
Virginia M. Y. Lee, Philadelphia, PA (US);
Francesco Piscitelli, Strongoli Marina, IT;
Amos B. Smith, III, Merion, PA (US);
James Soper, Cambridge, MA (US);
John Q. Trojanowski, Philadelphia, PA (US);
The Trustees Of The University Of Pennsylvania, Philadelphia, PA (US);
Abstract
The present invention is directed to carboxylic acid-containing pharmaceutical compounds where the carboxylic acid moieties have been substituted with cycloalkyl-dione derivatives, as well as tautomers and pharmaceutically acceptable salt forms thereof. These bioisosteric replacements improve the compound's ability to effectively cross the blood brain barrier and result in improved pharmacokinetic, toxicological, and/or safety profiles.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile