Pyrazolothiazole compound

Abstract

A compound represented by the formula (I) or pharmacologically acceptable salt thereof exhibits an excellent CRF receptor antagonism wherein X is a nitrogen atom or CH; Ris -A-A; Ais a single bond or a C1-6 alkylene group; Ais a hydrogen atom, a C1-6 alkyl group or a C3-6 cycloalkyl group, etc.; Ris -A-A; Ais a single bond or a C1-6 alkylene group; Ais a hydrogen atom, a C1-6 alkyl group, a C3-6 cycloalkyl group, a non-aromatic heterocyclic group, or a heteroaryl group, etc.; Ris a C1-6 alkyl group, a C3-6 cycloalkyl group, a C1-6 alkoxy group, a C3-6 cycloalkoxy C1-6 alkyl group, di-C1-6 alkyl amino group, a halogen atom, a cyano group, a formyl group, or a carboxyl group, etc; Ris a hydrogen atom or a C1-6 alkoxy group; Ris a halogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group; Ris a hydrogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, a C1-6 alkylthio group, or a C1-6 alkyl sulfinyl group etc.; and Ris a C1-6 alkyl group, a C1-6 alkoxy group, or a C1-6 alkylthio group.