The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 10, 2013
Filed:
May. 28, 2009
James C. Barrow, Arnold, MD (US);
Scott Harrison, Etkins Park, PA (US);
James Mulhearn, Saint Davids, PA (US);
Cyrille Sur, Harleysville, PA (US);
David L. Williams, Telford, PA (US);
Scott Wolkenberg, Jenkintown, PA (US);
Eric Hostetler, Collegeville, PA (US);
James C. Barrow, Arnold, MD (US);
Scott Harrison, Etkins Park, PA (US);
James Mulhearn, Saint Davids, PA (US);
Cyrille Sur, Harleysville, PA (US);
David L. Williams, Telford, PA (US);
Scott Wolkenberg, Jenkintown, PA (US);
Eric Hostetler, Collegeville, PA (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The present invention relates to novel amyloid binding compounds of formula (I) and methods for measuring effects of the compounds, by measuring changes of amyloid plaque level in living patients. More specifically, the present invention relates to a method of using the compounds of this invention as tracers in positron emission tomography (PET/) imaging to study amyloid deposits in brain in vivo to allow diagnosis of Alzheimer's disease. Thus, the present invention relates to use of the novel amyloid binding compounds as a diagnostic. The invention further relates to a method of measuring clinical efficacy of Alzheimer's disease therapeutic agents. Specifically, the present invention relates to novel aryl or heteroaryl substituted azabenzoxazole derivatives, compositions, and therapeutic uses and processes for making such compounds, or a pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof, wherein: X is O or S; A and Y independently are N, or CH.