The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 03, 2013
Filed:
Feb. 23, 2009
Applicants:
Hong-gang Wang, Palmyra, PA (US);
Roman Manetsch, Tampa, FL (US);
Xiangdong HU, Xi'an, CN;
Sameer Kulkarni, Tampa, FL (US);
Jiazhi Sun, Tampa, FL (US);
Inventors:
Hong-Gang Wang, Palmyra, PA (US);
Roman Manetsch, Tampa, FL (US);
Xiangdong Hu, Xi'an, CN;
Sameer Kulkarni, Tampa, FL (US);
Jiazhi Sun, Tampa, FL (US);
Assignees:
University of South Florida, Tampa, FL (US);
H. Lee Moffitt Cancer Center and Research Institute, Inc., Tampa, FL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 321/00 (2006.01); C07D 217/02 (2006.01); C07D 211/06 (2006.01); C07D 277/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present disclosure relates to acylsulfonamides and processes for their preparation. The processes involve a target-guided synthesis approach, whereby a thioacid and a sulfonyl azide are reacted in the presence of a biological target protein, a Bcl-2 family protein, to form the acylsulfonamide.