The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 03, 2013
Filed:
Jun. 26, 2006
Adelya K. Leshchiner, Cresskill, NJ (US);
Paul Konowicz, Arlington, MA (US);
Min-yeh Grace Chang, Brookline, MA (US);
Valentina Vasilyeva, Pomona, NY (US);
Adelya K. Leshchiner, Cresskill, NJ (US);
Paul Konowicz, Arlington, MA (US);
Min-Yeh Grace Chang, Brookline, MA (US);
Valentina Vasilyeva, Pomona, NY (US);
Genzyme Corporation, Cambridge, MA (US);
Abstract
Disclosed are highly resilient and cohesive gels formed by the cross-linking of hyaluronan or hylan, their salts or derivatives thereof, using divinyl sulfone (DVS) as the cross-linking agent. Also disclosed are viscoelastic fluids containing alkylsulfone groups covalently attached to the backbone of the polymer, formed by the mono-functionalization of the cross-linking monomer DVS with hyaluronan and/or hylan. Mechanical properties such as values of hardness and cohesiveness are specified by the rheological properties of the gels. Also disclosed are methods for the preparation of such products. They have use in many applications as injectable and/or implantable devices and as drug delivery systems.