The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 03, 2013
Filed:
May. 14, 2009
Bertha Louise Frederike Van Eck-smit, Leusden, NL;
Victorine Augustine Pinas, Amsterdam, NL;
Albert Dirk Windhorst, Alphen Aan Den Rijn, NL;
Bertha Louise Frederike Van Eck-Smit, Leusden, NL;
Victorine Augustine Pinas, Amsterdam, NL;
Albert Dirk Windhorst, Alphen Aan Den Rijn, NL;
Academisch Medisch Centrum Bij de Universiteit van Amsterdam, Amsterdam, NL;
Abstract
The invention is directed to radiolabelled MMP selective compounds, a processes for the preparation thereof, and uses thereof. The derivatives of the invention have formula (I) wherein Y represents O, CH, (CH), S, NH, or C(═O)NH; X represents 1-5 substituents, wherein said substituents can be the same or different and wherein at least one of said substituents comprises a radioisotope suitable for PET and/or SPECT and/or a β-emitter; Z is S; Q is chosen from the group consisting of 3-pyridyl and carboxyl; and R is chosen from the group consisting of C(═O)—NH—OH, (II), (III, (IV). The MMP selective compounds of the invention are selective for MMPs and can be used for the identification and treatment of unstable atherosclerotic plaques.