The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 27, 2013
Filed:
Dec. 03, 2010
Adrian Wiestner, Bethesda, MD (US);
Yihong YE, Potomac, MD (US);
Qiuyan Wang, Rockville, MD (US);
William C. Trenkle, Bethesda, MD (US);
Bidhan A. Shinkre, Ponda, IN;
Adrian Wiestner, Bethesda, MD (US);
Yihong Ye, Potomac, MD (US);
Qiuyan Wang, Rockville, MD (US);
William C. Trenkle, Bethesda, MD (US);
Bidhan A. Shinkre, Ponda, IN;
Abstract
Disclosed herein are novel hydrazone and diacyl hydrazine derivatives that are inhibitors of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Also disclosed are hydrazone and diacyl hydrazine derivatives as potent and selective inhibitors of the p97 ATPase. These agents provide useful tools for the study of protein degradation and other processes involving p97. Methods of treating diseases or disorders for which p97 inhibition and/or ER stress induction is an effective treatment with certain hydrazone and diacyl hydrazine derivatives are also disclosed.