The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 20, 2013
Filed:
Apr. 24, 2009
Tadeusz Krzysztof Wyrzykiewicz, Wyoming, OH (US);
Hagen Cramer, West Chester, OH (US);
Huihe Zhu, Cincinnati, OH (US);
Kevin James Finn, Blue Ash, OH (US);
Tadeusz Krzysztof Wyrzykiewicz, Wyoming, OH (US);
Hagen Cramer, West Chester, OH (US);
Huihe Zhu, Cincinnati, OH (US);
Kevin James Finn, Blue Ash, OH (US);
Nitto Denko Avecia, Inc., Milford, MA (US);
Abstract
A process for manufacturing an oligonucleotide which comprises removing β-eliminating phosphorus-protecting groups, in particular β-cyanoethyl protective groups from a protected oligonucleotide, wherein said removing comprises contacting the protected oligonucleotide with an amine solution in a solvent which preferably does not consist of pyridine, wherein the conjugate acid of the amine has preferably a pKa of greater than 11.5, and wherein the concentration of the amine in the solution is less than 0.5 mole/liters.