The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8513400 B1

PDF
Full Text
Expired
Date of Patent:
Aug. 20, 2013

Filed:

Dec. 18, 2009
Applicants:

Donna T. Ward, North Chelmsford, MA (US);

Kenneth W. Dobie, Del Mar, CA (US);

Eric G. Marcusson, San Francisco, CA (US);

Susan M. Freier, San Diego, CA (US);

Inventors:

Donna T. Ward, North Chelmsford, MA (US);

Kenneth W. Dobie, Del Mar, CA (US);

Eric G. Marcusson, San Francisco, CA (US);

Susan M. Freier, San Diego, CA (US);

Assignee:

Isis Pharmaceuticals, Inc., Carlsbad, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C12N 15/113 (2006.01);
U.S. Cl.
CPC ...
Abstract

Compounds, compositions and methods are provided for modulating the expression of HIF1α and/or HIF2α. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1α and HIF2α. Methods of using these compounds for modulation of HIF1α and/or HIF2α expression and for diagnosis and treatment of disease associated with expression of HIF1α and/or HIF2α are provided.


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