The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 20, 2013
Filed:
Mar. 05, 2011
Sharon Shacham, Newton, MA (US);
Michael Kauffman, Newton, MA (US);
Vincent P. Sandanayaka, Northboro, MA (US);
Sharon Shechter, Andover, MA (US);
Sharon Shacham, Newton, MA (US);
Michael Kauffman, Newton, MA (US);
Vincent P. Sandanayaka, Northboro, MA (US);
Sharon Shechter, Andover, MA (US);
Karyopharm Therapeutics, Inc., Newton, MA (US);
Abstract
The invention generally relates to the field of nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to new substituted-heterocyclic azole compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity such as in treating cancer and other neoplastic disorders, inflammatory diseases, disorders of abnormal tissue growth and fibrosis including cardiomyopathy, pulmonary fibrosis, hepatic fibrosis, glomerulonephritis, and other renal disorders, and for the treatment of viral infections (both acute and chronic).