The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 20, 2013
Filed:
Mar. 26, 2009
Romesh Chandra Boruah, Jorhat, IN;
Moyurima Borthakur, Jorhat, IN;
Madan Gopal Barthakur, Jorhat, IN;
Paruchuri Gangadhar Rao, Jorhat, IN;
Sudip Kumar Kar, Kolkata, IN;
Annalakshmi Chinniah, Kolkata, IN;
Suchandra Goswami, Kolkata, IN;
Pratap Kumar Das, Kolkata, IN;
Romesh Chandra Boruah, Jorhat, IN;
Moyurima Borthakur, Jorhat, IN;
Madan Gopal Barthakur, Jorhat, IN;
Paruchuri Gangadhar Rao, Jorhat, IN;
Sudip Kumar Kar, Kolkata, IN;
Annalakshmi Chinniah, Kolkata, IN;
Suchandra Goswami, Kolkata, IN;
Pratap Kumar Das, Kolkata, IN;
Council of Scientific and Industrial Research, New Delhi, IN;
Abstract
The present invention relates to preparation and biological evaluation of 3-acetoxy-17-acetamido-16-formyl-androst-5,17-diene (4) and 3-acetoxy2'-chloro-5-androsteno[17,16-b]pyridine (5) as gastric proton pump inhibitor and their comparison to that of omeprazole, a clinically employed anti-gastric ulcer drug. Compound (4) exhibited dose dependent inhibition of histamine-stimulated acid secretion in gastric parietal cell with an ICvalue comparable to cimetidine. No mortality or behavioral abnormality of Swiss albino mice was observed under single-dose level of 1 g/Kg body weight of compound (4). Compound (4) further exhibited excellent anti ulcer activity in vivo against indomethacin induced ulcer.