The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 20, 2013

Filed:

Sep. 12, 2011
Applicants:

Artem Gennady Evdokimov, Loveland, OH (US);

Richard Masaru Kawamoto, Lebanon, OH (US);

Angelique Sun Boyer, West Chester, OH (US);

Marlene Jan Mekel, Ross, OH (US);

Matthew Eugene Pokross, Hamilton, OH (US);

Richard Lee Walter, Jr., Hamilton, OH (US);

Inventors:

Artem Gennady Evdokimov, Loveland, OH (US);

Richard Masaru Kawamoto, Lebanon, OH (US);

Angelique Sun Boyer, West Chester, OH (US);

Marlene Jan Mekel, Ross, OH (US);

Matthew Eugene Pokross, Hamilton, OH (US);

Richard Lee Walter, Jr., Hamilton, OH (US);

Assignee:

Akebia Therapeutics, Inc., Cincinnati, OH (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/26 (2006.01); G01N 31/00 (2006.01); G06G 7/58 (2006.01);
U.S. Cl.
CPC ...
Abstract

The crystal structure of ligand-bound EGLN1 catalytic domain of prolyl hydroxylase is disclosed. These coordinates are useful in computer aided drug design for identifying compounds that regulate EGLN1 prolyl hydroxylase and thereby regulate HIF-regulated disorders.


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