The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 20, 2013
Filed:
Feb. 09, 2005
Laszlo Takacs, Newbury Park, CA (US);
Andras Guttman, San Diego, CA (US);
William S. Hancock, Brookline, MA (US);
Barry L. Karger, Newton, MA (US);
Manuel Duval, New London, CT (US);
Patrick Berna, Gaillon, FR;
Laszlo Takacs, Newbury Park, CA (US);
Andras Guttman, San Diego, CA (US);
William S. Hancock, Brookline, MA (US);
Barry L. Karger, Newton, MA (US);
Manuel Duval, New London, CT (US);
Patrick Berna, Gaillon, FR;
Northwestern University, Boston, MA (US);
Abstract
A method or platform for monoclonal antibody based biomarker discovery is disclosed. The method according to the invention provides for the integration of analyte collection, hybridoma screening and nanovolume integrated mass spectrometry (NVIMS) to achieve a robust screening system that is capable, for example, of cutting 4-6 years off of the classical biomarker discovery and development process. The invention provides a platform for the rapid, high-throughput production, isolation and characterization of, e.g., disease specific biomarkers together with highly specific monoclonal antibodies. The method of the invention has a variety of applications such as, but not limited to, drug testing, biohazard applications, ecological applications, physiological applications and/or pathology screening applications. The method of the invention is also capable of being performed or used as or with a high-throughput screening process or system of the invention.