The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 13, 2013
Filed:
Jun. 08, 2007
Wanbin Zhang, Shanghai, CN;
Fang Xie, Shanghai, CN;
Delong Liu, Shanghai, CN;
LI Luo, Shanghai, CN;
Genghong Hua, Shanghai, CN;
Jian Shang, Shanghai, CN;
Wanbin Zhang, Shanghai, CN;
Fang Xie, Shanghai, CN;
Delong Liu, Shanghai, CN;
Li Luo, Shanghai, CN;
Genghong Hua, Shanghai, CN;
Jian Shang, Shanghai, CN;
Shanghai Jiaotong University, Shanghai, CN;
Abstract
The invention affords C-symmetrical ruthenocene diphosphine ligands with surface chirality and their manufacture. The present invention uses (S)-(S)-1,1'-2(diphenylphosphino)-2,2′-2[(S)-4-isopropyloxazolinyl] ruthenocene as raw material and the product is prepared through two or three steps of reaction. At the action of trifluoroacetic acid, (S)-(S)-1,1′-2(diphenylphosphino)-2,2′-2[(S)-4-isopropyloxazolinyl] ruthenocene first removes oxazoline and gets ester amides compound which then carries out ester exchange or reduction alkylation and gets the product of ruthenocene diphosphine ligand with surface chirality. The ligands prepared with the structure as follows from the invention can be used in all kinds of metallic catalysis asymmetric reaction and has good reaction activity and stereoselectivity, wherein R is methyl or ethyl, Ris linear or branched alkyl, cycloalkyl, alkoxy, aryl, aralkyl and alkyl amino.