The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 13, 2013
Filed:
Aug. 21, 2007
Viswajanani J. Sattigeri, Gurgaon, IN;
Venkata P. Palle, Pune, IN;
Manoj Kumar Khera, Gurgaon, IN;
Ranadheer Reddy, Suryapet, IN;
Manoj Kumar Tiwari, Mumbai, IN;
Ajay Soni, New Delhi, IN;
Abdul Rehman Abdul Rauf, Buldane, IN;
Sony Joseph, Ernakulam, IN;
Arpita Musib, Bankura, IN;
Sunanda G. Dastidar, New Delhi, IN;
Punit Kumar Srivastava, Gurgaon, IN;
Viswajanani J. Sattigeri, Gurgaon, IN;
Venkata P. Palle, Pune, IN;
Manoj Kumar Khera, Gurgaon, IN;
Ranadheer Reddy, Suryapet, IN;
Manoj Kumar Tiwari, Mumbai, IN;
Ajay Soni, New Delhi, IN;
Abdul Rehman Abdul Rauf, Buldane, IN;
Sony Joseph, Ernakulam, IN;
Arpita Musib, Bankura, IN;
Sunanda G. Dastidar, New Delhi, IN;
Punit Kumar Srivastava, Gurgaon, IN;
Ranbaxy Laboratories Limited, New Delhi, IN;
Abstract
The present invention relates to β-hydroxy and amino substituted carboxylic acids, which act as matrix metalloprotease inhibitors, particularly diastereomerically pure β-hydroxy carboxylic acids, corresponding processes for the synthesis of and pharmaceutical compositions containing the compounds of the present invention. Compounds of the present invention are useful in the treatment of various inflammatory, autoimmune and allergic diseases, such as methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, wound healing disorders, pulmonary inflammation, acute respiratory distress syndrome, periodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by the over-expression and over-activation of a matrix metalloproteinase using the compounds.