The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 13, 2013
Filed:
Jan. 15, 2010
Gyoergyi Kovanyine Lax, Budapest, HU;
Eva Sipos, Budapest, HU;
Jozsef Barkoczy, Budapest, HU;
Balazs Volk, Budapest, HU;
Gyula Simig, Budapest, HU;
Ferenc Bartha, Tiszavasvari, HU;
Gyoergy Ruzsics, Hoegyesz, HU;
Adrienn Karasz, Budapest, HU;
Imre Kiraly, Salgotarjan, HU;
Kalman Nagy, Budapest, HU;
Gyoergyi Kovanyine Lax, Budapest, HU;
Eva Sipos, Budapest, HU;
Jozsef Barkoczy, Budapest, HU;
Balazs Volk, Budapest, HU;
Gyula Simig, Budapest, HU;
Ferenc Bartha, Tiszavasvari, HU;
Gyoergy Ruzsics, Hoegyesz, HU;
Adrienn Karasz, Budapest, HU;
Imre Kiraly, Salgotarjan, HU;
Kalman Nagy, Budapest, HU;
Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag, Budapest, HU;
Abstract
The present invention relates to a new process for the preparation of rosuvastatin [7-[4-(4-Fluorophenyl)-6-isopropyl-2-(methanesulphonyl-methyl-amino)-pyrimidin-5-yl]-(3R,51S)-dihydroxy-hept-6-enoic acid] of the formula (I) salts formed with bivalent cations, preferably with calcium or zinc ions, characterized in that rosuvastatin tert.-butylammonium salt is reacted with the appropriate bivalent cation, preferably with calcium or zinc ions in a mixture of a water immiscible or slightly miscible organic solvent and water and the formed salt is isolated.