The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 13, 2013
Filed:
Jun. 02, 2009
Shuntaro Furukawa, Mito, JP;
Taketo Ikeno, Niigata, JP;
Shinji Kato, Nagoya, JP;
Masashi Kawasaki, Osaka, JP;
Hisaki Kojima, Nagoya, JP;
Wataru Minagawa, Saitama, JP;
Naotaka Sawada, Ibaraki, JP;
Fuyuki Yamamoto, Tsukuba, JP;
Sachin Lohani, Annandale, NJ (US);
Yaling Wang, Westfield, NJ (US);
Shuntaro Furukawa, Mito, JP;
Taketo Ikeno, Niigata, JP;
Shinji Kato, Nagoya, JP;
Masashi Kawasaki, Osaka, JP;
Hisaki Kojima, Nagoya, JP;
Wataru Minagawa, Saitama, JP;
Naotaka Sawada, Ibaraki, JP;
Fuyuki Yamamoto, Tsukuba, JP;
Sachin Lohani, Annandale, NJ (US);
Yaling Wang, Westfield, NJ (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The present invention relates to a process for producing a hydrate of 3-(2,6-dichlorophenyl)-4-imino-7-[(2'-methyl-2′,3′-dihydro-1′H-spiro[cyclopropane-1,4′-isoquinolin]-7′-yl)amino]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one (Compound A) or of a pharmaceutically acceptable salt of Compound A and a crystalline form of Compound A or of a pharmaceutically acceptable salt of Compound A, which are useful in the field of treatment of various cancers as a kinase inhibitor, especially as a Weel kinase inhibitor.