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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8507473 B1

PDFFull Text
Expired
Date of Patent:
Aug. 13, 2013

Filed:

Sep. 10, 2009

[object object]

Applicants:

P. Douglas Boatman, San Diego, CA (US);

Benjamin R. Johnson, San Diego, CA (US);

Jae-kyu Jung, San Diego, CA (US);

Michelle Kasem, Chula Vista, CA (US);

Thomas O. Schrader, San Diego, CA (US);

Philip J. Skinner, San Diego, CA (US);

Steven Colletti, Princeton Junction, NJ (US);

Inventors:

P. Douglas Boatman, San Diego, CA (US);

Benjamin R. Johnson, San Diego, CA (US);

Jae-Kyu Jung, San Diego, CA (US);

Michelle Kasem, Chula Vista, CA (US);

Thomas O. Schrader, San Diego, CA (US);

Philip J. Skinner, San Diego, CA (US);

Steven Colletti, Princeton Junction, NJ (US);

Assignees:

Arena Pharmaceuticals, Inc., San Diego, CA (US);

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:

Fish & Richardson P.C.

Lyle W. Spruce

Primary Examiner:

Niloofar Rahmani

Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61K 31/437 (2006.01); A61K 31/55 (2006.01); A61P 3/06 (2006.01); A61P 3/10 (2006.01); A61P 9/10 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention is directed to certain 3H-imidazo[4,5-b]pyridin-5-ol derivatives of Formula (Ia) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the GPR81 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of GPR81 associated disorders, for example, dyslipidemia, atherosclerosis, atheromatous disease, hypertension, coronary heart disease, stroke, insulin resistance, impaired glucose tolerance, type 2 diabetes, syndrome X, obesity, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type 1 diabetes and acne.

Find Patent Forward Citations

Boatman, P.. (2013). [object object] (U.S. Patent No. 8507473). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/8507473

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