The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 13, 2013

Filed:

Feb. 20, 2012
Applicants:

Tim Fat Tam, Vaughan, CA;

Blaise N'zemba, Brampton, CA;

Regis Leung-toung, Mississauga, CA;

Yingsheng Wang, Toronto, CA;

Yanqing Zhao, Richmond Hill, CA;

Lily Yu, Woodbridge, CA;

Inventors:

Tim Fat Tam, Vaughan, CA;

Blaise N'Zemba, Brampton, CA;

Regis Leung-Toung, Mississauga, CA;

Yingsheng Wang, Toronto, CA;

Yanqing Zhao, Richmond Hill, CA;

Lily Yu, Woodbridge, CA;

Assignee:

Apotex Technologies Inc., Toronto, ON, CA;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 5/072 (2006.01); A61K 38/05 (2006.01);
U.S. Cl.
CPC ...
Abstract

A process for making pure crystalline D-isoglutamyl-D-tryptophan is provided which includes the step of deprotecting essentially pure N-tert-butoxycarbonyl-D-isoglutamyl-D-tryptophan or its diester to yield essentially pure D-isoglutamyl-D-tryptophan. A process is also provided for the preparation of pure mono ammonium salt of D-isoglutamyl-D-tryptophan from essentially pure N-tert-butoxycarbonyl-D-isoglutamyl-D-tryptophan. D-isoglutamyl-D-tryptophan, ammonium salt (1:1) is a stable pharmaceutical solid.


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